Diabetes mellitus is a type of metabolic disease, causing insufficient insulin secretion or increased resistance, characterized by hyperglycemia, rise in the concentration of glucose in the blood. If diabetes is not treated properly, metabolic syndrome appears, and in turn, intractable complications such as peripheral neuropathy and lower extremity arterial disease may occur.

Hyperlipidemia refers to a condition in which the amount of cholesterol or triglycerides is higher than normal. Fat content in the blood is deposited on the arterial wall, causing blood vessels to narrow and the risk of heart and cerebrovascular disease increase. When triglycerides are high, pancreatitis as well as atherosclerosis may occur, and cholesterol builds up in the walls of blood vessels, causing atherosclerosis and cardiovascular diseases such as angina pectoris, myocardial infarction, and stroke.